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Image Search Results
Journal: Journal of immunology (Baltimore, Md. : 1950)
Article Title: Innate Immune Activation during Salmonella Infection Initiates Extramedullary Erythropoiesis and Splenomegaly
doi: 10.4049/jimmunol.1001198
Figure Lengend Snippet: In vivo neutralization of EPO reduces splenic erythroid expansion and bacterial counts. C57BL/6 mice were infected i.v. with 5 × 105 attenuated Salmonella, and 250 μg monoclonal anti-EPO or isotype control-Ig was injected 2 and 4 d later. Seven days postinfection, spleens were harvested, splenic erythroid cell populations were examined by flow cytometry, and bacterial counts determined. Bar graphs show (A) mean Ter119+/CD71+ cells in the spleen ± SD and (B) mean bacterial counts ± SD for five mice per group. The mean percentage of Ter119+/CD71+ cells in the spleen and mean bacterial counts were significantly lower in anti-EPO–treated mice, as assessed by Student t test; *p < 0.05.
Article Snippet: In vivo blockade of EPO Salmonella -infected mice were injected i.v. with 250 μg
Techniques: In Vivo, Neutralization, Infection, Control, Injection, Flow Cytometry